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Consequently, we observed that this beneficial effect, after direct injury (permanent ligation) applied to one or two major vessels, could instantly oppose more general damage (maintained intra-abdominal hypertension, either high (grade III) or very high (grade IV)), as all blood vessels which can be compressed with increased intra-abdominal pressure

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The most frequently reported adverse effects were gastrointestinal in nature, generally mild to moderate in severity and transient, typically occurring during the dose-escalation period