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One large observational study of 461,382 patients taking GLP-1 medications found that 15.1% developed vitamin deficiencies over 12 months, including 13.6% with vitamin D deficiency, 0.0% with niacin deficiency, and 0.1% with thiamine deficiency
Reid IR, Baldock PA, Cornish J
In the UK, there are specific NHS criteria: Semaglutide 2.4mg (Wegovy) : NICE technology appraisal TA875 recommends this only within specialist weight management services and for a maximum of 2 years on the NHS [2] Liraglutide 3.0mg (Saxenda) : NICE technology appraisal TA664 specifies that treatment should only continue beyond 12 weeks if you've lost at least 5% of your initial body weight Clinical trials have demonstrated that most people regain weight after stopping GLP-1 medications
The hot flashes some users report represent another blood pressure-relevant effect
Week-by-Week Progress: Your First Month on GLP-1 Week 1: Adjusting to GLP-1 Treatment During the first week, your body starts adapting to the medication
The 7.5mg strength is a mid-dose titration step introduced after a patient has tolerated the 5mg dose for at least four weeks
