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S1 (PRISMA-ScR flow diagram)

Semaglutide typically reduces hemoglobin A1C by approximately 1.01.5 percentage points when taken consistently, as demonstrated in the SUSTAIN clinical trials

Epitalon appears to partially restore pineal function, acting as a true circadian regulator capable of re-entraining disrupted biological rhythms

Patients who stop taking their GLP-1 medication often regain weight and suffer from increased complications from uncontrolled diabetes and obesity, including increased risk of heart attack or stroke, plus an increased risk of metabolic syndromes like fatty liver disease

As economies grow, demand for chronic disease management and preventive care, such as obesity treatment, also rises, supporting market expansion

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