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Adjusting the dose and frequency is key in the maintenance phase

For many patients, their injections dont last long enough Some clinicians assume (incorrectly) that 1000 mcg of B12 should last patients at least 200 days, calculating from a 5 mcg daily requirement for the vitamin

The incidence of overcorrection was observed in 4 patients (16.7%) in the proactive group and 7 patients (28%) in the reactive group (p = 0.54), as shown in Table 2

For keeping vitamin B12 levels up, a common dose is 1000 mcg (1 mg) once a month

Switch to a different GLP-1 agonist like semaglutide , which some people tolerate better

Cox, Stacy J