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George Pavlou, who runs Gastroenterology Associates of New Jersey, told The Journal: Its crazy to think that our collective bowel dysfunction problems have gotten so bad that were literally running out of stool softeners. The proof is in the Amazon searches: Searches for laxative pills on Amazon have tripled in the past year alone, according to analytics firm Patter, per The Journal

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Close agreement observed between trials and estimates from the database analyses for all endpoints except one supported the fitness of the design and data for assessing cardiovascular effectiveness and safety