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Orforglipron (LY3502970) is a non-peptide GLP-1R agonist currently in clinical development that has demonstrated promising effects on glycemic control and body weight reduction, highlighting the continued expansion of GLP-1-based therapeutic strategies [4]

-Glutamylcysteine synthetase is composed of a heavy or catalytic (GCS-HS) and a light or modifier (GCS-LS) subunit