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Because the two peptides hit two separate receptors that both feed the same GH pulse, they are described in research as synergistic rather than additive: GHRH-driven and secretagogue-driven signals combine at the pituitary

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For example: Life expectancy gains continued steadily in the latter 20th century even as measured [total factor productivity] growth slowed, suggesting standard economic metrics may understate the true impact of health innovation on human wellbeing. Likewise, the GS analysis explicitly notes that GDP is a poor proxy for the societal value of healthcare innovation because it misses many quality-of-life benefits