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While glutathione is approved for certain medical applications, its use for cosmetic enhancement remains off-label, placing responsibility on providers and patients to navigate potential risks without regulatory guidance

Research has shown that phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first reaction in the serine synthesis pathway, was highly upregulated in metastatic breast cancer and was correlated to short patient survival times [135, 136]

doi:10.1016/j.bbagen.2012.09.008

This imbalance can lead to issues like fatigue, weaker immunity, and accelerated aging

However, mutations in the MTHFR gene typically result in a lack of folate required for methylation reactions

The benefits described are based on third-party studies