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In the ATTAIN-MAINTAIN trial, orforglipron's profile was "consistent with previous orforglipron Phase 3 studies." The most common adverse events were gastrointestinal-related and were generally mild-to-moderate in severity, which is expected for the GLP-1 class
503A patient-specific compounding pharmacies operate under a different statutory framework - but their ability to compound essentially a copy of these drugs has also been constrained since semaglutide and tirzepatide were removed from the FDA shortage list in 2025
Future evidence may highlight specific populations, not yet covered by guidance, who may benefit from taking them. For food and beverage, this will create challenges as well as opportunities but staying across the science is essential for exploiting them
Z., Cardoso, S
Sales of GLP-1 medications continue to rise, and Ozempic and Wegovy generate more than $25 billion in combined sales in 2024
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