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The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference

Without these controls, high-cost therapies can be approved and dispensed without any plan-level review of whether a lower-cost alternative exists

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Activation of glucagon-like peptide-1 receptor promotes neuroprotection in experimental autoimmune encephalomyelitis by reducing neuroinflammatory responses

This underscores the value of individualized, physician-supervised dosing rather than a fixed one-size-fits-all schedule