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(2010) used EDC in acidic medium to activate and protonate BSA, prior to the addition to maleimide-functionalized PEG-PLA nanoscaffolds

Nomiya A, Naruse T, Niimi A et al: On- and post-treatment symptom relief by repeated instillations of heparin and alkalized lidocaine in interstitial cystitis

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Body weight had not meaningfully separated from placebo in the first week of any published trial