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Clinical implication: Even within therapeutic daily totals, susceptible patients can manifest hepatocellular injury, especially with repeated 34 g/day exposure

- For weakness_signal, capture clinician-described weakness, frailty, deconditioning, sarcopenia-like weakness, or similar functional weakness signals

NCT03987919) enrolled 1879 participants across 128 sites in the USA, Argentina, Australia, Brazil, Canada, Israel, Mexico and the UK between 30 July 2019 and 15 February 2021

At the 48-week mark, between 64% and 100% of participants in the GLP-3R groups experienced weight reductions of at least 5%, compared to 27% in the placebo group

Antidepressant effects of Noopept were further examined 1 day after CPAR evaluation in the behavioral despair test