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This helped to show that NNMT is a key target in metabolic research. Neelakantan and colleagues then expanded research involving small-molecule NNMT inhibitors
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The expression of the VD metabolism genes CYP2R1 and CYP27A1 (25-hydroxylase), CYP27B1 (1--hydroxylase), and vitamin D receptor (VDR) were downregulated in the livers of mice fed an HFD (GSH- deficient) compared with control diet-fed group
doi: 10.1152/ajpgi.2000.278.1.G18 57 MomanyF
We next challenged the mice with 0.2 mM oleic acid medium (dissolved by BSA in 0.9% NaCl solution) to investigate the effect of GSTM2 on the rapid formation of LDs
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