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For women, menopause accelerates this to roughly 30% loss in the first five post-menopausal years alone

It is not FDA-approved for treating any condition

[94] Its effects, depending on dosage, include an increase in sodium excretion by the kidneys, an increase in urine output, an increase in heart rate, and an increase in blood pressure

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SUMOylation determines turnover and localization of nephrin at the plasma membrane