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The primary theoretical safety concern is sustained activation of the HGF/c-Met proto-oncogenic pathway, which could theoretically promote tumor initiation or growth

Retatrutide showing promise in obesity (and type 2 diabetes)

However, some clinics offering the retatrutide-cagrilintide combination use a ratio of approximately 5:1 (retatrutide to cagrilintide), which at a retatrutide dose of 10-12 mg would put cagrilintide at 2.0-2.5 mg

B12 deficiency can also be an issue if you have had weight loss surgery, have a very poor diet, or follow extreme or restrictive diets for a long time

Cagrilintide may offer a slightly better tolerability profile with more predictable side effect patterns, though this is based on comparative analysis rather than head-to-head trials

Safety during pregnancy and breastfeeding may vary