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long-term discontinuation data are still emerging from Phase 3 TRIUMPH trials
Clinically, elevated levels of endogenous GLP-1 have been observed in patients with sepsis (6.35-fold increase), end-stage renal disease (4.46-fold), and burns (2.96-fold), indicating a common physiological response to critical illness (Lebherz et al., 2017)
We were particularly concerned about this limitation, as PCSK1 is lowly expressed in adult cells (16)
People who don't eat much meat, are vegetarian or vegan, or on restricted diets (such as weight loss diets), may find it a challenge to maintain ideal levels
Currently, many guidelines and recommendations encourage the use of anti-obese medications to achieve this goal (11, 12)
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