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1B) wild-type flies exposed to APAP at a concentration of 100 mM, 50 mM, 25 mM, 12.5 mM, or 0 mM (vehicle control)

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18 Zhao et al attempted to modify EA using thiazole derivatives of uric acid to strengthen its GST-inhibitory effects

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Cytosolic and nuclear NAD + are often considered a shared pool as NAD + diffuses through nuclear pores 58 , and importantly, the concentrations of NAD + in the cytosol, nucleus, and mitochondria mirror the K m of NAD + -consuming enzymes localized to the corresponding compartment, hence these enzymes are sensitive to compartmental fluctuations in NAD + levels 77