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Some studies on human adipocytes demonstrated that increased fat cell size correlates with impaired whole-body metabolic regulation and systemic insulin resistance

Colombel JF, Panaccione R, Bossuyt P et al (2017) Effect of tight control management on Crohns disease (CALM): a multicentre, randomised, controlled phase 3 trial

A peptide with greater potency at GIPR than GCGR may produce a different experimental profile from a molecule with more evenly distributed receptor activity

In addition, although combination therapy exerted beneficial effects on both -cell mass and function in an early phase of diabetes in this study, -cell mass was increased more clearly and to a larger extent, compared to the extent of -cell function improvement

Muscle tissue is metabolically active, burning calories even at rest

The combination may be used to help with blood sugar control, weight loss, or both