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Description

Retatrutide is an investigational once-weekly injectable triple agonist targeting GLP-1, GIP, and glucagon receptors, developed by Eli Lilly

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Most GLP-1RAs, aside from a new oral formulation of semaglutide (Rybelsus tablets), are administered subcutaneously via pen-like devices (once daily to once weekly) due to poor oral bioavailability, and all are renally excreted 1

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doi: 10.1001/jama.2021.1831 84 WildingJPHBatterhamRLCalannaSDaviesMVan GaalLFLingvayIet al

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