This typically involves: Intrinsic factor antibodies (highly specific for pernicious anaemia, though sensitivity is only 50%) [12] [28] Gastric parietal cell antibodies (more sensitive but less specific) Coeliac serology if malabsorption is suspected Consideration of upper gastrointestinal endoscopy in selected cases, particularly with autoimmune gastritis/pernicious anaemia NICE guidance emphasises that treatment should not be delayed whilst awaiting antibody results if clinical features strongly suggest deficiency, as irreversible neurological damage can occur
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Gene profiling studies showed that GHK upregulates the expression of 54 genes known as tumor suppressors while simultaneously downregulating 48 oncogenic genes (Pickart et al., 2018)
Sikiric P, Separovic J, Anic T, et al
Instead of efficiently storing incoming calories as fat, treated adipocytes become more metabolically active, breaking down stored triglycerides and releasing them for energy use