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Individuals most likely to benefit include: Those with pernicious anemia People with gastrointestinal disorders (e.g., Crohns disease, celiac disease, chronic gastritis) Patients following bariatric (weight loss) surgery Older adults with absorption difficulties Strict vegetarians or vegans at risk for deficiency People taking medications that can decrease vitamin B12 levels Laboratory testing usually confirms B12 deficiency before starting injections

And when you try to supplement it

This is why dermatologist-supervised IV therapy is non-negotiable

However, you may need to talk with a doctor in some cases, especially if they require a physical exam, blood test, or imaging test to make a diagnosis

Here's the mechanism: after 8-10 hours of fasting, your body needs amino acids (from protein) to trigger muscle protein synthesis

Importantly, IR is a measured number, not an intrinsic property, so a different method of measuring IR can give slightly different numbers