Overview: Two Distinct Pathways for GH Regulation with Peptides Growth hormone secretion from pituitary somatotrophs is regulated by multiple neurohormonal pathways that evolved to provide fine-tuned control over this critical metabolic hormone
Because of their effectiveness, use of GLP-1 medications has grown rapidly among people of reproductive age
doi:10.2147/DMSO.S425642
[14] [41] In December 2025, the FDA approved an oral version of semaglutide for weight management, using the same brand name (Wegovy) as the injectable version
In Conclusion Until there is more evidence-based research on the impact of GLC-1 receptor agonists on anesthesia, specifically conscious sedation, DOCS Education recommends a medical consult with the patients PCP or endocrinologist, and absent the strong recommendation to the contrary from their prescribing physician, have the patient withhold their weekly injectable GLP-1 receptor antagonist one week before sedation, and their daily GLP-1 receptor agonist on the day of the sedation appointment, and be NPO 6 hours before the appointment as usual
In contrast, certain studies and reports have indicated that there were not any significant differences between general perioperative adverse outcomes (Raven et al