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In a glucose-deprived tumor microenvironment (TME), which is generally seen when nutrients are depleted, high level of lactate is converted into pyruvates (LDH-catalyzed reverse reaction) and then cancer cells can utilize pyruvate for the TCA cycle through the action of pyruvate kinase [81]

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In addition, in conditions inducing the secretory phase (high levels of E2 and P4), the organoids showed a pseudostratified, folded glandular epithelial appearance with cilia, and upregulation of decidualization markers such as PAEP [53,54,55]

G., Saegusa, D., Fujita, M