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There was no significant difference between semaglutide and placebo in gastric emptying when corrected for week-20 body weight
However, obesity also appears to play an independent role in CKD risk and progression by triggering increased inflammatory signaling, oxidative stress, and gut microbiome disturbance, as well as premature cellular aging and dysfunction
GLP-1 specifically inhibits glucagon secretion, which is especially advantageous for individuals with type-2 diabetes (T2DM) who often have increased glucagon levels
In clinical trials of Wegovy, participants lost an average of 15% of their body weight and more than half lost more
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