Die off goes through three stages
In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )
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Proton pump inhibitors reduce the risk of neoplastic progression in patients with Barretts esophagus
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TI 07.003