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Annual Review of Nutrition, 41(1), 333361

Treatment eligibility, dosing, and results vary by individual

However, several concerns remain

Obesity and weight retention involve complex metabolic and hormonal factors far beyond simple calories in versus calories out

Other pathological correlations include a reduction in hippocampal serotonergic 5-HT1A receptors (Lai et al., 2011), abnormal fatty acids in the prefrontal cortex and hippocampus suggesting demyelination (Nihonmatsu-Kikuchi et al., 2013), and a reduction in antioxidant enzymes in the hippocampus and anterior cingulate cortex (Luo et al., 2022)

Timeline : Noticeable results in 612 months