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Also, hydrolysis with a range of enzymes is used to release DPP4-inhibitory peptides (Reference Ishikawa, Hira and Inoue69,Reference Lacroix and Li-Chan85Reference Connolly, Piggott and FitzGerald90)
However, some candidate mechanisms have been proposed, namely, the impairment of AKT translocation through the activation of atypical PKC, and the activation of PP2A [132,133]
Overall, the use of the GLP-1 receptor agonist-SGLT-2 inhibitor combination was associated with a 30% lower risk of MACE (7.0 v 10.3 per 1000 person years
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