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These processes that involve oxygen result in waste products called free radicals
Some mutations can lead to various neurological conditions, including neonatal mitochondrial encephalopathy, sensorineural hearing loss, axonal neuropathy, and, less commonly, motor neuron disease ( Riboflavin also supports the antioxidant defense system by aiding the regeneration of other antioxidants, such as glutathione, from oxidized glutathione (GSSG), since riboflavin, in the form of FAD, is necessary for glutathione reductase to play its role in converting GSSG (43)
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SURMOUNT-5 added another critical data point by directly comparing tirzepatide to semaglutide, which was previously considered the gold standard among GLP-1 agonists
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This MOF nanosystem could react with GSH to generate Mn 2+ , TCPP, and GSSG, leading to decomposition of MOF
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