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Critically, an early vicious cycle emerges between MQC dysfunction and localized inflammationinflammatory cytokines suppress core MQC components, while MQC failure-generated ROS and mtDNA further exacerbate inflammation (10, 86)

Meimaridou E, Goldsworthy M, Chortis V et al (2018) NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice

Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

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