P., & Gatlin, L
There is some indication that semaglutide might decrease the diversity of the gut microbiome, a key indicator of its health, but we need more human-based studies to know for sure whats going on
The researchers considered a variety of kidney issues including death from kidney causes, significant decline in kidney function, the initiation of chronic kidney replacement therapy and the onset or persistence of macroalbuminuria (high levels of the protein albumin in the urine)
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If adverse effects are the primary concern, dose adjustment or symptomatic management strategies might allow continuation