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But when total weight loss exceeds 20%, as it does in many GLP-1/GIP patients, that 25% lean mass fraction represents a significant absolute deficit in muscle tissue
The question is whether the added glucagon receptor effects, including the heart rate increase, will enhance, diminish, or have no effect on that protection
The authors responded
Schaeffer EM, Srinivas S, Adra N, An Y, Bitting R, Chapin B, et al
Nevertheless, in all studies the digoxin concentrations remained within the therapeutic range