Q: Beyond litigation, what are the primary business strategies that branded companies are using to counter the rise of compounding pharmacies
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Abstract Recent large clinical trials on sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, with the aim of verifying cardiovascular safety, have revealed that these medications have a preventative advantage on adverse cardiovascular outcomes, including worsening of heart failure and deterioration of nephropathy, in patients with type 2 diabetes (T2D)
These tradeoffs are not merely theoretical: in the pilot phase of the PRECIDENTD pragmatic trial, participants assigned to dual therapy had substantially lower medication fill rates and higher discontinuation than those on monotherapy, driven largely by side effects, cost, and access [36]