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Large-scale clinical trials with semaglutide (STEP 1) found that roughly 40% of total weight loss came from lean body mass (LBM), which is higher than the roughly 25% expected during typical physiological weight loss (the so-called "quarter fat-free mass rule")
Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, et al
A patient with strong tolerance might progress to 5 mg after two weeks rather than four
Leal AD, Qin R, Atherton PJ, et al., Alliance for Clinical Trials in Oncology
The American Journal of the Medical Sciences,343 (1), 2-9
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