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A 2024 phase 2 RCT (Hansen et al., eClinicalMedicine) found a 2.6% reduction in hip bone mineral density within 52 weeks in a specific study population using semaglutide at 1.0 mg weekly
Sex Differences in Metabolic Regulation and Insulin Sensitivity
Consistent with this premise, trends in our study suggested an increase in physical activity among GLP-1 RA users, though statistical significance was not achieved
Koohpeyma F, Siri M, Allahyari S, Mahmoodi M, Saki F, Dastghaib S