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Or rather, a lack of B12 can cause headaches

The goal here is to correct a specific medical problem

The optimal frequency, duration, and total number of courses for humans is entirely unknown

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Additionally, the absence of microbiota, or the presence of broad-spectrum antibiotic-induced dysbiosis, triggered the NOD-like receptor family pyrin domain (PYD)-containing 6 (NLRP6)/Caspase 11 (Casp11) inflammasome-mediated pathway and subsequent loss of iEANs and enteric neuropathy (Muller et al., 2020a)