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doi: 10.1038/s41467-019-09234-6

For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM, that explain poor responders to their medications. The biological basis of GLP-1 resistance is still unknown and is likely complex

It wont pass the Senate, but in general, we should take a long hard look in the mirror about cutting Medicaid, which supports quite a few vulnerable populations

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Its medicinal-chemistry program, described in detail by Kruse and colleagues, introduced several deliberate substitutions into the amylin backbone: residues borrowed from rat amylin (which does not readily form fibrils) to blunt the aggregation tendency, an engineered salt bridge to stabilize the central helix, and a C 20 fatty-diacid moiety attached through a linker to promote reversible binding to serum albumin