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This hormonal shift leads to irregular menstrual cyclesperiods might be late, skipped, or unusually heavy or light, and these patterns can persist for several months or years before menopause (defined as twelve consecutive months without a period) is reached

The receptor selectivity difference matters clinically because GIP activation independently promotes satiety, reduces appetite-driven eating, and may enhance energy expenditure through brown adipose tissue activation

The Bradford method 36 was employed to determine the soluble protein content in the leaves

The co-primary endpoints follow the FDA's established framework for obesity drugs: mean percent change in body weight from baseline and the proportion of participants achieving at least 5% body weight reduction

Although our knowledge on these liver flukes and available techniques tackling the infections have increased significantly over the past several decades, gaps still exist, which hinder control, let alone elimination (Box 1) (12, 356358)