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This mechanistic disruption likely explains the prolonged prothrombin time (PT) and bleeding tendencies observed in treated groups
N Ballatori, SM Krance, S Notenboom, S Shi, K Tieu, CL Hammond
The biological action of gut microbiota interrupts the control of the cell cycle by generating genotoxins which may lead to oxidative stress and a chronic inflammatory state (268)
However, excessive or dysregulated TLR9 activation has been implicated in sepsis-related organ injury ( Importantly, bacteria-induced mitochondrial dysfunction can trigger multiple forms of regulated cell death beyond apoptosis
Nat Med (2013) 19:114752
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