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1 Its massively complicated. You have changes in your peripheral systems (neurons and immune cells), which make your spinal cord neurons hyperexcitable

Back to the STEP study, patients taking SSRIs are more prone to side effects of semaglutide, at a rate of 97.6% to 100% depending on the trial, compared to 86.7% to 95.3% for those not on SSRIs

If you weigh under 50 kg, your GP may recommend a lower dose

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Dr Gordon, Thank you for this excellent article