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First characterised in receptor pharmacology studies published in the late 1990s (DOI 10.1046/j.1365-2265.1998.00629.x), ipamorelin was specifically designed to improve on the selectivity limitations of earlier GHRPs such as GHRP-2 and hexarelin, both of which produced meaningful elevations of cortisol and prolactin alongside GH stimulation

The major adverse side effects are gastrointestinal: nausea, vomiting, diarrhea, constipation and acid reflux

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