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In one clinical trial, Semaglutide has been shown to reduce the risk of major cardiovascular events in patients with cardiovascular disease without diabetes

Through 52 weeks, we also saw no nimacimab-associated neuropsychiatric signal, and in combination with semaglutide, we did not see an additive GI burden

Loss or damage to the ICCs appears to be a dominant abnormality [3, 6, 11], where altered immune function with a shift from M2 to M1 macrophage expression and impaired regulation of haem oxygenase 1 leading to increased oxidative stress may be responsible [6, 11]

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