Abraham, J
Monitor renal function in patients reporting adverse reactions to Wegovy that could lead to volume depletion, especially during initiation and escalation of Wegovy Severe Gastrointestinal (GI) Adverse Reactions: Use of Wegovy has been associated with GI adverse reactions, sometimes severe
This ultimately leads to better blood sugar control, weight loss, and improved overall health for individuals with diabetes
Potential benefits being investigated include: Cognitive performance : Some small-scale human studies have shown mixed results on cognitive tasks among participants receiving GLP-1 receptor agonists, with no consistent pattern of improvement established in randomised trials to date Cognitive decline : Observational data from diabetes cohorts suggest that patients prescribed GLP-1 agents may experience different rates of cognitive deterioration compared to those on other diabetes medications, though causality cannot be established Dementia risk : Population-based studies have indicated a possible association between GLP-1 receptor agonist use and dementia diagnoses, though these findings require confirmation in prospective trials Neuroimaging markers : Early research is examining potential effects on brain structure and function, but definitive evidence of preservation of brain volume has not been established Important limitations and considerations: Limited human trial data : Most evidence comes from animal models or observational studies
Abbreviations MSM: methyl sulphonyl methane Vit C: vitamin C GPx: glutathione peroxidise GST: glutathione transferase GR: glutathione reductase HO: heme oxygenase ROS: reactive oxygen species RNS: reactive nitrogen species NO: nitric oxide CO: carbon monoxide GSH: glutathione
Semaglutide stands as a shining example of innovation in diabetes care
