The most concerning aspect of this condition is increased fat around (and inside) the internal organscalled visceral obesity
( PMID: 37026881 ) Ito A, Kamata A, Nozaki A, Ando T, Kawakami A (2019) Hypothyroidism could be a potential factor to prolong subcutaneous nodules of exenatide once weekly: a case report
Crucitta et al
Feeling colder is not a listed side effect of semaglutide drugs, Wegovy , Ozempic , or Rybelsus
Pan H, Wang B, Lv W, Jiang Y, He L (2015) Esculetin induces apoptosis in human gastric cancer cells through a cyclophilin D-mediated mitochondrial permeability transition pore associated with ROS
Even though this dose is nearly 500 times the RDA, it seems to be very common