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Both groups received the maximum tolerated dose of their medication: Tirzepatide group: 10 mg or 15 mg weekly (Zepbound) Semaglutide group: 1.7 mg or 2.4 mg weekly (Wegovy) Participants had a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related health condition

Higher doses or additional medications Repeated injections without sustained improvement Increasing side effects with diminishing therapeutic return At this stage, pain is no longer simply a symptomit reflects underlying regulatory imbalance

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2 Excessive Dosing 2 Excessive Dosing Some people believe more is better. High, unsupervised doses of any compound even vitamins can stress the body