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Therefore, l-ARG supplementation as single compound might be considered an attractive alternative approach to ED management in reason of greater compliance and safety profile, and generally more affordable costs, compared to PDE5i

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Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)