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The importance of targeting the underlying pathophysiology of T2DM rather than focusing management on reducing plasma glucose levels, as is currently recommended, has recently been debated [8]

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Nat Commun 4:2760 Gold PE (2003) Acetylcholine modulation of neural systems involved in learning and memory

In previous GLP-1- or exendin-P5-bound active structures 3,4 , the ECD shows a fully extended open conformation, whereas in the peptide 5-bound active-like structure 12 , the ECD is less extended since it makes fewer interactions with the truncated peptide 5

37 DengY.ZhangY.LiY.XiaoS.SongD.QingH.et al (2012)