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Researchers should not expect dramatic changes within days or weeks

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Food and Drug Administration and other agencies to update guidelines for lifestyle interventions in pediatric clinical trials to incorporate state-of-the-art approaches to quantifying, monitoring and evaluating physical activity, adherence to diet, and to the accurate measurement of body composition beyond the current reliance on body mass index (BMI), a suboptimal metric of overweight and obesity in adolescents

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In April 2004, JHU reported that inhibition of FAS with C-75 altered food-intake, resulting in significant weight loss in animals, with no evidence of neurotoxicity