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Notably, a clinical study demonstrated that T2DM patients receiving insulin therapy experienced significantly higher rates of pancreatitis compared to those treated with GLP-1RAs, and notably, no pancreatitis cases have been reported in clinical trials of the novel GLP-1RA Cotadutide, indicating that a comprehensive risk assessment of GLP-1RAs for pancreatic cancer remains premature pending additional data on these novel medications [8]

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doi: 10.1371/journal.pone.0095968 125 RyanSVCarrithersSLParkinsonSJSkurkCNussCPoolerPMet al

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The nucleus localization significantly increases the effectiveness of DNAzyme therapy