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Some experts caution that surgical intervention for large CMN with surgical procedures such as excision and grafting, laser ablation, dermabrasion, and chemical peels may not only prevent the detection of melanoma within the treated areas but may in fact increase the risk of malignant degeneration by altering the biological behavior of residual melanocytes

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Among several oxalate-degrading bacteria in the human gut microbiota, Oxalobacter formigenes represents a major reservoir of oxalate-metabolizing genes

The consensus process also identified areas in need of further research, such as the development and evaluation of diagnostic and outcome questionnaires, agreement of threshold glycaemia levels for reliable diagnosis, evaluation of the therapeutic efficacy of acarbose for symptoms of early dumping syndrome and assessment of the relative efficacy of short-acting versus long-acting somatostatin analogues