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doi: 10.1016/j.tifs.2024.104829 169

Indeed, preclinical studies conducted in renal carcinoma model reported that the VEGFR2 inhibitor sunitinib increases vascular mimicry under hypoxia by transforming tumor cells into endothelial-like cells resulting in tumor resistance [301]

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As a case in point, Li and co-workers loaded dihydroartemisinin (DHA) into iron-based MOFs to design a peroxidase-like nanoreactor (termed DHA@MIL-101 NR) for synergistic CDT-ferroptotic therapy (Figure 5C) (Yang et al., 2022a)

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